June 14, 2015

Black Box Warnings of Common Drugs

Drug or Class
Warnings
Amiodarone
Pulmonary toxicity, avoid with pacemakers
ACEi, ARB
Fetal toxicity
Abacavir/Lamuvidine
Lactic acidosis, hepatomegaly, hepatitis
Acetaminophen
Liver failure
Aminoglycosides
Ototoxicity, nephrotoxicity
Anabolic steroids
Hepatitis, liver tumors, blood lipid changes
Aspirin
Reyes syndrome in children
Atomoxetine
Suicide
Beta blocker
MI with abrupt stopping
Calcineurin inhibitors (tacrolimus)
Cancer
Diuretics
Volume, electrolyte depletion
Enoxaparin (LMWH)
Spinal/epidural hematoma
Estrogen
Heart attack, stroke, breast cancer, pulmonary embolism in post-menopausal
Infliximab
Infection, malignancy
Iron
Fetal toxicity
Isotretinoin
Birth defects
Ketoconazole
Hepatotoxicity
LABA
Sudden death
Lamotrigine
Rash
Metformin
Lactic acidosis
Methadone (opiod)
Respiratory depression, QT prolongation
Metoclopramide
Tardive dyskinesia
NSAID
GI bleeding, ulcers
Olanzapine
Delirium, sedation, avoid in dementia related psychosis
Paroxetine (SSRI)
Suicide
Pioglitazone
Worsen heart failure, avoid with NYHA class 3, 4
SGLT2 inhibitors
Ketoacidosis
Stavudine
Lactic acidosis
Telithromycin
Respiratory failure with myasthenia gravis
Warfarin
Bleeding